Defeated #1 Seed or Defending Champion at a
Slam (or both) - Open Era
PlayerBeat #1 Seed
Rafael Nadal8 --- RG 6, WM 1, US 1
Boris Becker5 --- WM 4, US 1
Ivan Lendl4 --- AO 1, RG 1, US 2
Jim Courier3 --- AO 1, RG 2
Mats Wilander3 --- AO 1, RG 1, US 1
Kevin Curren3 --- AO 1, WM 2
Yevgeny Kafelnikov3 --- RG 2, US 1
Pat Cash2 --- AO 2
Marat Safin2 --- AO 2
Karol Kucera2 --- AO 1, RG 1
Roger Taylor2 --- AO 1, WM 1
Stefan Edberg2 --- AO 1, WM 1
Novak Djokovic2 --- AO 1, WM 1
Roscoe Tanner2 --- AO 1, US 1
Andre Agassi2 --- AO 1, US 1
Sergi Bruguera2 --- RG 2
Robin Soderling2 --- RG 2
Ken Rosewall2 --- RG 1, WM 1
Roger Federer2 --- WM 2
Arthur Ashe2 --- WM 1, US 1
Jimmy Connors2 --- WM 1, US 1
John McEnroe2 --- WM 1, US 1
Tomas Berdych2 --- WM 1, US 1
Andy Murray2 --- WM 1, US 1
Jan Kodes2 --- US 2
Pete Sampras2 --- US 2
Mark Cox1 --- AO
Mal Anderson1 --- AO
Karl Meiler1 --- AO
Ross Case1 --- AO
John Newcombe1 --- AO
Mark Edmondson1 --- AO
Kim Warwick1 --- AO
Hank Pfister1 --- AO
Ramesh Krishnan1 --- AO
Mark Philippoussis1 --- AO
Greg Rusedski1 --- AO
Alberto Martin1 --- AO
Younes El Aynaoui1 --- AO
David Ferrer1 --- AO
Stanislas Wawrinka1 --- AO
Cliff Richey1 --- RG
Patrick Proisy1 --- RG
Tom Okker1 --- RG
Harold Solomon1 --- RG
Adriano Panatta1 --- RG
Brian Gottfried1 --- RG
Jose Higueras1 --- RG
Christophe Roger-Vasselin1 --- RG
Jonas Svensson1 --- RG
Michael Chang1 --- RG
Magnus Norman1 --- RG
Ramon Delgado1 --- RG
Dominik Hrbaty1 --- RG
Guillermo Canas1 --- RG
Tommy Robredo1 --- RG
Gustavo Kuerten1 --- RG
Tom Gorman1 --- WM
Sandy Mayer1 --- WM
Vitas Gerulaitis1 --- WM
Bjorn Borg1 --- WM
Peter Doohan1 --- WM
Michael Stich1 --- WM
Andrei Olhovskiy1 --- WM
Richard Krajicek1 --- WM
Ivo Karlovic1 --- WM
Cliff Drysdale1 --- US
Dennis Ralston1 --- US
Manuel Orantes1 --- US
Dick Stockton1 --- US
Bill Scanlon1 --- US
Alexander Volkov1 --- US
Paul Haarhuis1 --- US
Cedric Pioline1 --- US
Jaime Yzaga1 --- US
Petr Korda1 --- US
Patrick Rafter1 --- US
Arnaud Clement1 --- US
Juan Carlos Ferrero1 --- US
Juan Martin Del Potro1 --- US
Defeated two #1 Seeds, same year

Roger Taylor  1970
d. Tony Roche, Australian Open QF
d. Rod Laver, Wimbledon R16


Boris Becker  1989
d. Ivan Lendl, Wimbledon SF
d. Ivan Lendl, US Open F


Rafael Nadal  2008
d. Roger Federer, Roland Garros F
d. Roger Federer, Wimbledon F


Rafael Nadal 2013
d. Novak Djokovic, Roland Garros SF
d. Novak Djokovic, US Open F